Curating the Clinical Genome

We are pleased to announce the 7th Curating the Clinical Genome conference, which aims to bring together the international clinical genomics and biodata communities to discuss best practices for the clinical use of genomic data, including variant interpretation, clinical utility, and the consensus generation of curated knowledge.

This event will be of interest to a wide group of medical genomics researchers, clinicians and clinical scientists practicing genomic medicine, companies developing solutions for clinical genomics and data scientists interested in genomic data sharing.

The sharing of genetic data from clinical diagnostic testing and the generation of consensus-curated knowledge is vital for delivering on the promise of genomic medicine. The growing recognition of the power of global data sharing has led to the establishment of major initiatives, such as ClinGen and DECIPHER consortia, which have spearheaded this conference series. The focus of this year’s meeting is to bring together these and other national/regional initiatives to develop common standards (guidelines and resources), share best practices, integrate the recent research findings and help drive patient benefits.

This conference will be a hybrid meeting – with onsite or virtual attendance. The programme will also include short oral presentations selected from abstracts, posters, poster pitches and a panel discussion on iterative reporting where more panel members will be invited from the registered delegates.

‘Clinical Application of MAVE Data’ workshop

After the conference, on the afternoon of 12 July, a workshop will be jointly hosted by the scientific committee of the Curating the Clinical Genome and the Mutational Scanning Symposium to discuss the potential use of mutational scanning data in variant classification in clinical practice. The registration for this face-to-face workshop will be taken separately from the conference, and the number of participants will be limited.

The conference will start at approximately 12.00 on Monday, 10 July and close at approximately 13.30 on Wednesday, 12 July 2022. All times are in BST. See the time where you are here.

Discussions will focus on a variety of exciting topics, including:

• Genetic architecture and locus heterogeneity
• Genetic pleiotropy and allelic heterogeneity
• Non-coding variation and polygenic risk scores
• Computational approaches
• Functional assays
• Variant classification recommendations
• Iterative reporting (panel discussion)

Clinical Application of MAVE Data workshop (12 July 2023)

The post-conference workshop will start at approximately 14.00 and close at 18.30 on Wednesday, 12 July 2023. See the workshop programme here.

Scientific programme committee

Leslie G. Biesecker
NIH-National Human Genome Research Institute, USA

Julia Foreman
EMBL-EBI, UK

Aimé Lumaka
University of Kinshasa, Democratic Republic of Congo

Meredith Weaver
American College of Medical Genetics & Genomics, USA

Keynote speaker

Ambroise Wonkam
Johns Hopkins University, USA

Confirmed speakers

Haico van Attikum – Leiden University, the Netherlands
Leslie G. Biesecker – NIH-National Human Genome Research Institute, USA
Nadia Carstens – University of the Witwatersrand, South Africa
Sandra Cooper – University of Sydney, Australia
Segun Fatumo – LSHTM & MRC/UVRI Uganda Research Unit, UK/Uganda
Elizabeth McNally – Northwestern University, USA
Erin R. Riggs – Geisinger Health System, USA
Carlo Rivolta – University of Basel, Switzerland/University of Leicester, UK
Zornitza Stark – Victorian Clinical Genetics Services, Australia
Lisenka Vissers – Radboud University, the Netherlands
Nicky Whiffin – University of Oxford, UK
Andrew Wilkie – University of Oxford, UK
Caroline Wright – University of Exeter, UK
Sarah Wynn – Unique, UK

Organisers – Wellcome Connecting Science

Jemma Hume, Conference & Events Organiser
Zoey Willard, Conference & Events Organiser
Laura Wyatt, Senior Manager – Events and Policy
Nagehan Ramazanoglu Bahadir, Scientific Programme Officer

Registration deadline: 13 June 2023 (in person) | 3 July 2023 (virtual)

Deadlines close at 23.59 BST.

The in-person registration fee includes:

• Full access to scientific programme: oral and poster presentations, and networking on campus
• Access to the online conference portal to network with online participants
• Meals (lunch and dinner) and refreshments during the conference. Breakfast will be provided for delegates who have booked onsite accommodation.
• Recordings of the live-stream sessions, which will be available ‘on-demand’ for four weeks after the event ends

Virtual registration fee includes:

• Access to the virtual event portal (Log in details will be emailed a few days before the event starts)
• Live-stream sessions, including posters and online networking channels
• Recordings of the live-stream sessions, available ‘on-demand’ for four weeks after the event ends.

* To promote more inclusive scientific discussions with international colleagues at our conferences, virtual delegates based in Lower and Middle-Income Countries can register for free (see list of countries here).

If you are an editor or journalist, please contact the conference organiser for more information about the discounted fee.

Payments: Please note that payment can only be made with Mastercard or Visa credit cards.

Accommodation
Booked accommodation is for the nights of 10 and 11 July 2023.
Please note: there is limited onsite accommodation and this will be allocated on a first-come, first-served basis; therefore, early registration is recommended.

If you wish to book campus accommodation either side of the conference dates, please contact the Hinxton Hall Conference Centre directly.

Accommodation services phishing scam – please be vigilant. More information.

Travel visas
Citizens of many countries can travel to the UK to attend a course or conference without needing a visa. Please check the UK government website for visitor information: https://www.gov.uk/standard-visitor.

Confirmed attendees requiring a letter to support a visa application should contact the event organiser.

Bursaries

Bursary deadline: 18 April 2023

A limited number of registration bursaries are available to attend this conference in person (up to 50% of the registration fee). Priority will be given to PhD students submitting abstracts who are facing financial barriers.

To apply, please use the dedicated bursary application link on the registration site. Please answer the bursary-related questions and submit an abstract before midnight UK time on the bursary deadline for your application to be considered.

Additional funding opportunities
Visit our support page for additional financial support currently available.

Abstract deadline: 16 May 2023

We welcome abstracts from all areas relevant to the main themes of the meeting, for both oral and poster presentations. Several oral presentations will be chosen from the abstracts submitted. Presenters of oral presentations are expected to be onsite for the duration of the conference, whereas those presenting posters can do so in person or virtually.

Abstracts will only be considered from registered delegates. Please use our online abstract submission system and follow the instructions given to ensure your abstract is submitted correctly. All abstracts must be submitted by the deadline. You can make changes to your submitted abstract before of the deadline by log into your account and following the instructions

If you have already completed your registration and subsequently wish to submit an abstract, or wish to submit a second abstract, please follow these instructions.

The scientific programme committee will assess your abstract after the deadline has passed and you will be notified whether you have been selected to present an oral or poster presentation.

Poster boards onsite will accommodate 118 cm high by 84 cm wide (A0- portrait) of printed material. Accepted abstracts will appear in the conference programme book; poster board numbers will be allocated at the conference.

All those accepted for a poster presentation will be given the opportunity to upload a short video describing their work.

With thanks to our sponsors

If you are interested in supporting this meeting, please contact the sponsorship manager.

See our sponsorship page for information about the benefits.

Curating the Variome

Keynote lecture by Sir John Burn at Curating the Clinical Genome 2021.

Delegate feedback from 2021 conference

“I thoroughly enjoyed all the topics and lively discussions. I learned of the new trends and evolving solutions in some of the variant curation problems. Most importantly, I was impressed with the intensive work in targeted therapy.”

“The program was concise and well designed. There was enough time for discussion. The balance between scientific and practical presentations was excellent.”

“The conference was well-organised. It was possible to explore different topics, all of them very interesting and relevant.”

“I appreciated all the extra efforts that went into making the conference materials (poster, talks, discussion, Q&A) so readily accessible. It helps immensely to be able to re-review a presentation.”