Mouse Models of Disease: Improving Reproducibility of Pathology Endpoints in Challenge Models

The lack of reproducibility in biomedical science, particularly mouse
model analyses, is hindering advances in our understanding of human
disease and the development of novel therapies. This 3-day meeting will
address this problem by sharing best practices in histopathology to
ensure the generation of accurate data from mouse models.

The meeting aims to bring together veterinary and human pathologists,
scientists and technical specialists working with mouse models in
academic and industrial research. The programme will start with a review
of approaches to practical mouse pathology. This session will be
accessible to students and experienced scientists who are new to mouse
models and will enable participants to gain expertise in creating and
interpreting reproducible mouse pathology data.

A major focus of this year’s meeting will be the techniques used to
investigate the pathology in the respiratory and gastrointestinal tracts
in challenged and non-challenged phenotyping studies. Throughout the
programme an emphasis will be placed on understanding the influence of
environmental effects and experimental challenges on pathology endpoints
and their potential effects on the reproducibility of data.

This meeting has been CPD approved by the Royal College
of Pathologists (17 credits).

The meeting will start at approximately 09:45 on Tuesday, 9 February and close at approximately 16.45 on Thursday, 11 February 2016.

Topics will include:

• Mouse pathology: back to basics
• Infectious diseases
• Environmental factors
• Infection models
• Nutrition and diet
• Microbiota
• Lung function
• Respiratory disease models
• Imaging and validation
• Reproducibility of lung cancer models

Scientific programme committee
Mark Arends University of Edinburgh, UK
Cory Brayton Johns Hopkins School of Medicine, USA*
Laurence Fiette Institut Pasteur,
France
Aude Roulois GlaxoSmithKline, UK
Cheryl Scudamore MRC Harwell, UK
Mohamed Slaoui Sanofi R&D, France*
Jacqui White Wellcome Trust Sanger Institute, UK
Jonathan Williams Royal Veterinary College, UK

Confirmed speakers
Nicolau Beckmann Novartis Institutes for BioMedical
Research, Switzerland
Anton Berns The Netherlands Cancer Institute, The Netherlands
Noel Downes Sequani, UK
Craig Franklin University of Missouri, USA
John Grainger University of Manchester, UK
Patrick Hardy Sanofi Pasteur, France
Deon Hildebrand GlaxoSmithKline, UK
Dominique Kagele The Jackson Laboratory, USA
Kevin Maloy University of Oxford, UK
Wayne Mitzner Johns Hopkins University, USA
Jonathan Stauber IMABIOTECH, France
Graham Tobin Harlan Laboratories, UK

Conference organiser
Lucy Criddle Wellcome Genome Campus, UK

*Funding generously provided by the Charles Louis Davis Foundation.

Registration Fees:

The registration fee includes entrance to the lectures and poster
sessions, an abstract book, meals (lunch and dinner) and refreshments
during the conference. Breakfast will be provided for delegates who have
booked accommodation.

Registration deadline: Closed

Accommodation
Accommodation is provided for the nights of 9 and 10 February 2016.
Please note there is limited on-site accommodation and this will be
allocated on a first-come first-served basis. Therefore, early
registration is recommended.
If you wish to book onsite accommodation either side of the conference
dates, please contact the Conference Centre directly.

Travel visas
Contact the conference organiser if you require a letter to support a
travel visa application. Note that letters will be provided to confirmed
registrants.

Non-European Economic Area or Swiss nationals may be required to have a
visa to enter the UK.
Early application is strongly advised, as this process can take 6-8 weeks
or longer.

Please visit the following websites for further information:
UK Border Agency website: www.ukba.homeoffice.gov.uk/visas-immigration/

Information for general visitors and business visitors: www.ukba.homeoffice.gov.uk/visas-immigration/visiting/business/business-activities/

Please use the links below to access further information and to apply for
a bursary to attend this meeting:

BSTP: http://www.bstp.org.uk/events/bstpwellcome-trust-mouse-models-of-disease/

Journal of Comparative Pathology: http://www.journals.elsevier.com/journal-of-comparative-pathology/news/the-journal-of-comparative-pathology-educational-trust/

Laboratory Animals: http://www.lal.org.uk/funding-and-opportunities/bursaries/

Pathological Society: http://www.pathsoc.org/index.php/grants-lectures-awards/travel-grants

We welcome abstracts from all areas relevant to the main themes of the
meeting, for oral and poster presentations. Several oral presentations
will be chosen from the abstracts submitted.

Please register prior to submitting your abstract. Please note: abstracts will only be considered from registered delegates.

The scientific programme committee will assess your abstract after the
deadline has passed and you will be notified whether you have been
selected for an oral or poster presentation.

Poster boards onsite will accommodate 118 cm high by 84 cm wide (A0-
portrait) of printed material. Accepted abstracts will appear in the
conference programme book and poster boards will be allocated at the
conference.

Abstract deadline: Closed

Abstract guidelines

• Format & Font: Prepare your abstract in Microsoft Word in 11-point Ariel Font.
• Title: The title should be concise and be in bold, sentence case.
• Author names: The presenting author’s name must be the first name to appear on the list of authors. Underline the name of the presenting author. For each author give the forename followed by the surname.
• Affiliations: Please list the authors and affiliations directly under the title, separated by one empty line, and followed on additional lines as necessary. Indicate each author’s affiliation with a superscript numeral following the surname.
• Abstract length: should not exceed one 1.5-spaced page. The total word limit is 400 words (to include title, authors, affiliations and abstract narrative).
• Abstract narrative: must be clear and concise. Clearly describe the problem you are addressing, the results to date and any conclusions you can draw from them, so that your abstract can be evaluated by the programme committee. Avoid saying in effect ‘a solution to XYZ problem will be presented’. Please ensure that your abstract is checked for correctness of spelling and grammar in advance of submission.
• Subheadings: Please avoid the use of subheadings in the abstract narrative.
• References: A separate list of references at the end of the abstract is not necessary.
• File name: should be the same as the surname of the presenting author.
• Download a sample abstract document (Microsoft Word), which can be used for formatting purposes.